Rx Information

Phenergan Suppository 25 mg.

Generic Name:  Promethazine -- Rectal Suppository


This medication is used to prevent nausea and vomiting. Also used as a sedative.


You may take one (1) or two (2) every four (4) hours, as needed for nausea and vomiting.

Unwrap suppository. Lie down on your left side with your right knee bent (if left-handed, lie on your right side with your left knee bent). Push the suppository into the rectum with your finger. Remain lying down for a few minutes and avoid having a bowel movement for an hour or longer so that the medication will be absorbed. Do not use more of this medication than is prescribed.


May cause drowsiness, dizziness, or thickening of mucous. Less frequent effects include blurred vision; dryness of the mouth, nose, and/or throat; feeling faint; sensitivity to the sun; decreased sweating; and, increased appetite. Notify Dr. Burden if you develop shortness of breath, flushing in the face, muscle spasms, or itchiness.


Do not consume alcohol while using this medication. Phenergan may cause increased sensitivity to sunlight. Wear protective clothing and sunscreen and avoid sunlamps.

Consult your obstetrician prior to taking this medication if you are pregnant or nursing.


Phenergan may interact with other medications. It is extremely important for you to inform Dr. Burden of all medications that you take, both prescription and over-the-counter.

If you are taking anti-depressants, drugs to treat an overactive thyroid, lithium, or narcotic pain medication, Dr. Burden will advise you on any changes you need to make while taking Phenergan.


Use extreme caution performing tasks that require alertness. Use sugarless candy or gum for relief of dry mouth. For motion sickness, use 30-60 minutes before traveling.

If you miss a dose, take as soon as remembered. Do not take if it is almost time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Refrigerate away from light and moisture.

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